Endothelial cell change

About this calculator

Enter endothelial cell density from two specular microscopy reports to see the change in cells per square millimetre and as a percentage, with optional hexagonality and coefficient of variation.

What you need

• The date and endothelial cell density from each test
• Hexagonality and coefficient of variation, if listed
• Both tests from the same microscope and corneal area

How it is calculated

Absolute change = later − earlier density. Percentage decrease = 100 × (earlier − later) ÷ earlier; an increase is labelled as an increase in measured density. Hexagonality and coefficient of variation changes are shown in percentage points.

What the result can and cannot tell you

Counts depend on the area sampled and image quality, and guttae or swelling make them harder to read in Fuchs dystrophy. A higher count on its own does not show that cells have regrown. Decisions about prognosis or a transplant stay with your cornea specialist.

References

1. Specular microscopy in clinical practice
2. Objective assessment of the corneal endothelium in Fuchs endothelial dystrophy
3. Netra Eye Institute: Fuchs dystrophy

Related

• Keratoconus scan comparison
• Corneal pain and light sensitivity diary
• Fuchs dystrophy guide
• All eye calculators

For information only. These tools explain numbers and do not replace an eye examination or your eye doctor’s advice. Values you enter stay in your browser.