Netra Restoration Therapy (NRT) – A multi-targeted therapy that synergistically addresses the vascular, metabolic, oxidative, and inflammatory contributors involved in Dry AMD.
Dry AMD is not primarily a photoreceptor disease
Dry AMD is a chronic degenerative disorder of the RPE–Bruch’s membrane–choriocapillaris complex driven by aging-related metabolic failure, oxidative stress, chronic low-grade inflammation, and impaired choroidal perfusion. Photoreceptor loss occurs secondarily after RPE dysfunction.
Vascular Dysregulation and Impaired Choroidal Perfusion
Impaired choroidal perfusion and venous clearance reduce oxygen and nutrient delivery to the RPE while limiting removal of metabolic waste. This promotes hypoxia, oxidative stress, and toxin accumulation beneath the retina, accelerating RPE dysfunction, drusen formation, and progressive retinal degeneration over time.
Impaired choroidal perfusion and venous clearance
Impaired choroidal perfusion and venous clearance reduce oxygen and nutrient delivery to the RPE while limiting removal of metabolic waste. This promotes hypoxia, oxidative stress, and toxin accumulation beneath the retina, accelerating RPE dysfunction, drusen formation, and progressive retinal degeneration over time.
Oxidative Stress
Oxidative stress from light exposure, high oxygen demand, and mitochondrial dysfunction damages RPE cells and Bruch’s membrane. This leads to lipid peroxidation, protein misfolding, and cellular injury, accelerating drusen formation, impairing RPE function, and increasing vulnerability of the macula to progressive degeneration.
Low-Grade Chronic Ocular Inflammation
Dry AMD is characterized by persistent, low-grade inflammation within the RPE–Bruch’s membrane complex. Complement activation, microglial activation, and cytokine release create a chronic inflammatory environment that disrupts tissue repair, promotes extracellular deposits, and gradually weakens retinal support structures, contributing to slow but progressive macular damage.
Aging-Related Metabolic Failure
With aging, the RPE’s ability to recycle photoreceptor outer segments and clear metabolic waste declines. Mitochondrial inefficiency and reduced lysosomal function lead to accumulation of lipofuscin and debris, overwhelming cellular defenses and impairing retinal homeostasis, ultimately predisposing the macula to degeneration in dry AMD.
Dry AMD involves impaired blood flow, oxidative stress, chronic inflammation, and age-related metabolic failure of the retinal support system. Netra Restoration Therapy (NRT) targets these root factors by improving choroidal perfusion and venous clearance, reducing oxidative and inflammatory stress, and supporting RPE metabolism—helping preserve retinal function and slow disease progression.
Impaired choroidal perfusion and venous clearance—often driven by underlying vascular dysregulation—reduce oxygen and nutrient delivery to the RPE while limiting removal of metabolic waste. Abnormal vascular tone, endothelial dysfunction, and impaired autoregulation lead to unstable or insufficient choriocapillaris flow and venous congestion. This creates chronic hypoxia, oxidative stress, and toxin accumulation beneath the retina, accelerating RPE dysfunction, drusen formation, and progressive retinal degeneration over time. Netra Restoration Therapy (NRT) is designed to support ocular microcirculation and venous clearance, helping improve perfusion dynamics and metabolic exchange at the choriocapillaris–RPE interface. By enhancing blood flow regulation and drainage, NRT aims to reduce tissue hypoxia and waste buildup, supporting a healthier retinal environment and slowing degenerative stress on the macula.
The macula is highly susceptible to oxidative stress due to intense light exposure, high oxygen consumption, and age-related mitochondrial decline. Excess reactive oxygen species damage RPE mitochondria, lipids, and proteins, impairing cellular repair and promoting drusen formation. Netra Restoration Therapy (NRT) targets this pathway by supporting antioxidant defenses and mitochondrial resilience within retinal tissues. By reducing oxidative burden and improving cellular energy efficiency, NRT helps protect RPE cells from cumulative oxidative injury, preserving their ability to maintain photoreceptor health and retinal homeostasis over time.
Dry AMD is driven in part by persistent, low-grade inflammation involving complement activation, microglial response, and chronic cytokine signaling. This ongoing inflammatory state disrupts normal retinal tissue repair, damages Bruch’s membrane, and perpetuates RPE dysfunction. Netra Restoration Therapy (NRT) focuses on modulating inflammatory signaling rather than simply suppressing symptoms. By supporting cytokine balance and reducing inflammatory stress within the retinal microenvironment, NRT may help limit chronic immune-mediated damage, creating conditions more favorable for tissue stability and long-term retinal support.
Our signature Netra Restoration Therapy is a unique treatment method available exclusively at Netra Eye Institute, which has shown to halt AMD progression, improve visual acuity, reduce foggy/hazy vision, improve contrast sensitivity and reduce glare.
The Mechanism of Action (MOA) of Netra Restoration Therapy works by enhancing ocular blood flow through the regulation of vascular function, reducing oxidative stress and ocular inflammation, increasing neurotrophin levels and neuroprotection, and reducing ferroptosis.
The potential for visual improvement depends on the severity of retinal damage present at the time of treatment for Wet AMD. Taking these factors into account, our therapeutic approach has been shown to result in:
Stops vision loss progression by reducing the ocular inflammation, regulating ocular blood flow and nourshing the retinal cells.
Improvement in visual field by restoring
dormant and unhealthy retinal cells.
An improvement of at least one line on the distance and near vision eye chart.
Improved contrast vision, making it easier to distinguish shapes, edges, and details.
Improvement in color, brightness perception and clarity making it easier to see in low-light or nighttime conditions, thereby supporting safer mobility and daily activities.
Reduced glare, less light sensitivity, and improved comfort in bright environments, such as sunlight, headlights, or digital screens.
Patients experience considerable reduction
in eye pain and eye strains.
Patients often report feeling “healthier overall,” not just in their eyes.
I recently completed my three weeks of Netra Restoration Therapy and I am already seeing major improvements with the reduction in my eye prescription correction numbers. Netra Eye Institute is not just a well equipped clinic with modern ophthalmic instruments but is also backed up by professional and patient-caring staff. Thank you Dr. Gandapodi for your services and care.
– Sarang - Grateful Netra Patient
Netra Restoration Therapy is grounded in contemporary biomedical research demonstrating that many eye diseases are driven by reduced ocular blood flow, ongoing neurodegeneration, and cellular stress. Scientific studies show that improving vascular regulation enhances oxygen and nutrient delivery to the retina and optic nerve, while supporting neurotrophin activity and neuroprotection helps preserve vulnerable nerve cells. At the same time, controlling oxidative stress, ferroptosis, and chronic inflammation is critical to slowing tissue damage and disease progression. Netra Restoration integrates these evidence-based principles into a comprehensive approach designed to support long-term eye health and visual function.
Want to learn more about Netra Restoration Therapy and holistic eye treatments or need help to schedule an appointment for a consultation?
Call us at (732)-503-9999 or fill out the contact us form below.
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