Netra Restoration Therapy (NRT) – A multi-targeted therapy that synergistically addresses the vascular, metabolic, oxidative, and inflammatory contributors involved in Wet AMD.
Wet Age-Related Macular Degeneration (Wet AMD) is a complex, progressive retinal disease driven by multiple overlapping biological, vascular, inflammatory, and systemic factors. Because no single mechanism is responsible for its onset or progression, relying on a single treatment approach often addresses only part of the problem. A multi-factorial treatment strategy is therefore essential for achieving better disease control, preserving vision, and improving long-term outcomes.
Wet AMD Is Not Caused by a Single Pathway
Wet AMD develops through a combination of abnormal blood vessel growth (neovascularization), chronic inflammation, oxidative stress, impaired retinal metabolism, and structural degeneration of the macula. While anti-VEGF injections target abnormal vessel growth, they do not directly address inflammation, cellular damage, or underlying metabolic dysfunction. A multi-factorial approach acknowledges that Wet AMD is a disease of multiple interacting systems rather than a single defect.
Chronic Inflammation Plays a Central Role
Research increasingly shows that low-grade, chronic inflammation contributes to retinal tissue damage and the progression of Wet AMD. Inflammatory cytokines, immune dysregulation, and complement system activation can continue damaging retinal cells even when neovascular leakage is controlled. Addressing inflammatory drivers through supportive therapies, lifestyle modifications, and systemic health optimization can help reduce ongoing retinal stress.
Impaired choroidal perfusion and venous clearance
Impaired choroidal perfusion and venous clearance reduce oxygen and nutrient delivery to the RPE while limiting removal of metabolic waste. This promotes hypoxia, oxidative stress, and toxin accumulation beneath the retina, accelerating RPE dysfunction, drusen formation, and progressive retinal degeneration over time.
Oxidative Stress and Cellular Damage Must Be Addressed
The retina has one of the highest metabolic demands in the body, making it especially vulnerable to oxidative stress. Free radical damage accumulates over time, weakening retinal cells and accelerating degeneration. Nutritional support, antioxidant strategies, and mitochondrial health play an important role in protecting retinal tissue alongside conventional therapies.
Vascular Health Extends Beyond the Eye
Wet AMD is closely linked to systemic vascular health. Conditions such as hypertension, diabetes, poor circulation, and endothelial dysfunction can worsen retinal blood flow and contribute to disease progression. A comprehensive treatment plan must consider cardiovascular health, blood sugar regulation, and overall circulation, rather than focusing only on the eye itself.
Structural and Functional Retinal Support Is Essential
Even when abnormal blood vessels are controlled, retinal cells may remain weak or damaged. Supporting retinal repair, cellular nourishment, and tissue resilience is critical for stabilizing vision. Functional improvements often depend on restoring a healthier retinal environment, not just suppressing active disease features.
Disease Progression Varies Between Individuals
Wet AMD does not progress the same way in every patient. Genetic predisposition, lifestyle factors, environmental exposure, and systemic health conditions all influence disease behavior. A multi-factorial approach allows treatment to be personalized, adapting to each individual’s unique risk factors and progression pattern.
Long-Term Management Requires More Than Symptom Control
Even when abnormal blood vessels are controlled, retinal cells may remain weak or damaged. Supporting retinal repair, cellular nourishment, and tissue resilience is critical for stabilizing vision. Functional improvements often depend on restoring a healthier retinal environment, not just suppressing active disease features.
Structural and Functional Retinal Support Is Essential
Anti-VEGF therapy is highly effective at controlling leakage and swelling, but it often requires repeated, long-term injections. Without addressing underlying contributors such as inflammation, oxidative stress, and metabolic imbalance, disease activity may persist or recur. A broader approach aims not only to manage symptoms but also to improve the internal conditions that allow the disease to progress.
Quality of Life Depends on Holistic Vision Care
Vision loss affects more than eyesight—it impacts independence, mental well-being, and daily functioning. Supporting overall eye health, systemic balance, nutrition, and lifestyle empowers patients to play an active role in their care, leading to better adherence, improved resilience, and enhanced quality of life.
Anti-VEGF injections help control abnormal blood vessel growth and leakage in Wet AMD, but they do not address the underlying causes of the disease. Wet AMD is driven by chronic inflammation, oxidative stress, metabolic dysfunction, and compromised vascular health, which can continue to damage retinal tissue even when injections are effective. A holistic, integrative approach is therefore needed to support retinal health more completely by addressing these root factors and promoting long-term stability rather than short-term symptom control.
When blood flow to the layer behind the retina (the choroid)is too low, the retina can become “under-supplied” with oxygen and nutrients. This chronic shortage puts stress on the macula and can push the eye to release signals that encourage new blood vessel growth. In Wet AMD, those new vessels are abnormal and leaky, which leads to fluid/bleeding and faster vision changes. The study above supports the idea that lower choroidal perfusion islinked to higher risk of developing the wet (neovascular) form.
Inflammation is the body’s defense response—but when it becomes chronic in the eye, it can start harming healthy tissue. In Wet AMD, ongoing inflammation can damage the retinal support layer (RPE) and surrounding structures, weakening barriers that normally keep the retina dry and stable. This inflammatory environment also “turns up” growth signals that can promote abnormal vessel growth (neovascularization) and leakage. This paper explains how inflammation and blood-vessel growth are closely connected in neovascular (wet) AMD.
Oxidative stress is a buildup of harmful “reactive”molecules that can injure cells over time—especially in sensitive tissues like the retina. When oxidative stress damages retinal cells, the eye may respond by releasing factors that encourage new blood vessels to grow. In Wet AMD, that response can contribute to the formation of the abnormal leaky vessels that threaten central vision. This study supports the idea that oxidative stress can drive multiple forms of abnormal eye blood-vessel growth, including models relevant to Wet AMD.
Our signature Netra Restoration Therapy is a unique treatment method available exclusively at Netra Eye Institute, which has shown to halt AMD progression, improve visual acuity, reduce foggy/hazy vision, improve contrast sensitivity and reduce glare.
The Mechanism of Action (MOA) of Netra Restoration Therapy works by enhancing ocular blood flow through the regulation of vascular function, reducing oxidative stress and ocular inflammation, increasing neurotrophin levels and neuroprotection, and reducing ferroptosis.
The potential for visual improvement depends on the severity of retinal damage present at the time of treatment for Wet AMD. Taking these factors into account, our therapeutic approach has been shown to result in:
Stops vision loss progression by reducing the ocular inflammation, regulating ocular blood flow and nourshing the retinal cells.
Improvement in visual field by restoring
dormant and unhealthy retinal cells.
An improvement of at least one line on the distance and near vision eye chart.
Improved contrast vision, making it easier to distinguish shapes, edges, and details.
Improvement in color, brightness perception and clarity making it easier to see in low-light or nighttime conditions, thereby supporting safer mobility and daily activities.
Reduced glare, less light sensitivity, and improved comfort in bright environments, such as sunlight, headlights, or digital screens.
Patients experience considerable reduction
in eye pain and eye strains.
Patients often report feeling “healthier overall,” not just in their eyes.
I recently completed my three weeks of Netra Restoration Therapy and I am already seeing major improvements with the reduction in my eye prescription correction numbers. Netra Eye Institute is not just a well equipped clinic with modern ophthalmic instruments but is also backed up by professional and patient-caring staff. Thank you Dr. Gandapodi for your services and care.
– Sarang - Grateful Netra Patient
Netra Restoration Therapy is grounded in contemporary biomedical research demonstrating that many eye diseases are driven by reduced ocular blood flow, ongoing neurodegeneration, and cellular stress. Scientific studies show that improving vascular regulation enhances oxygen and nutrient delivery to the retina and optic nerve, while supporting neurotrophin activity and neuroprotection helps preserve vulnerable nerve cells. At the same time, controlling oxidative stress, ferroptosis, and chronic inflammation is critical to slowing tissue damage and disease progression. Netra Restoration integrates these evidence-based principles into a comprehensive approach designed to support long-term eye health and visual function.
Want to learn more about Netra Restoration Therapy and holistic eye treatments or need help to schedule an appointment for a consultation?
Call us at (732)-503-9999 or fill out the contact us form below.
.webp)
